Mouse Sh3bp5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sh3bp5
Locus ID	24056
Kit Components	GA204876G1, Sh3bp5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204876G2, Sh3bp5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204876G3, Sh3bp5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347585, NM_011894
Synonyms	AI606498; Sab; SH3BP-5
Summary	Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.[UniProtKB/Swiss-Prot Function]

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