Mouse Izumo1r activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Izumo1r
Locus ID	64931
Kit Components	GA206501G1, Izumo1r gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206501G2, Izumo1r gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206501G3, Izumo1r gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022888, NM_176807
Synonyms	0910001L11Rik; C86255; Folbp3; Folr4; Juno
Summary	Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963).[UniProtKB/Swiss-Prot Function]

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