Mouse Nemf activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nemf
Locus ID	66244
Kit Components	GA206659G1, Nemf gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206659G2, Nemf gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206659G3, Nemf gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025441, NM_181665
Synonyms	1500011I12Rik; 4933405E14Rik; Sdccag1
Summary	Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Nemf is important for the stable association of Ltn1 to the complex. May indirectly play a role in nuclear export.[UniProtKB/Swiss-Prot Function]

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