Mouse Ankrd9 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ankrd9
Locus ID	74251
Kit Components	GA209802G1, Ankrd9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209802G2, Ankrd9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209802G3, Ankrd9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175207, NM_001361916, NM_001361917
Synonyms	2500003O20Rik
Summary	Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly. Implicated in different cellular processes, like copper homeostasis and cell proliferation.[UniProtKB/Swiss-Prot Function]

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