Mouse Tmem108 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tmem108
Locus ID	81907
Kit Components	GA211203G1, Tmem108 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211203G2, Tmem108 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211203G3, Tmem108 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178638, NM_001359465
Synonyms	AI462967; B130017P16Rik; R74726
Summary	Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons (PubMed:28096412). Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport (PubMed:17287360). In hippocampal neurons, required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes (PubMed:21849472, PubMed:27605705).[UniProtKB/Swiss-Prot Function]

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