Mouse Kiss1r activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kiss1r
Locus ID	114229
Kit Components	GA212408G1, Kiss1r gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212408G2, Kiss1r gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212408G3, Kiss1r gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_053244, NM_001359010
Synonyms	Gpr54; KiSS-1
Summary	Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.[UniProtKB/Swiss-Prot Function]

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