Mouse Trp53bp2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trp53bp2
Locus ID	209456
Kit Components	GA212936G1, Trp53bp2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212936G2, Trp53bp2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212936G3, Trp53bp2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_173378
Synonyms	53BP2; AI746547; ASPP2; PPP1R13A; Tp53bp2; X98550
Summary	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).[UniProtKB/Swiss-Prot Function]

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