Mouse Dock10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dock10
Locus ID	210293
Kit Components	GA212975G1, Dock10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212975G2, Dock10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212975G3, Dock10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001285927, NM_175291
Synonyms	9330153B10Rik; A630054M16Rik; Jr4; Jr5; mKIAA0694; R75174; ZIZ3; Zizimin3
Summary	Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway (PubMed:25851601). Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression (PubMed:27502165).[UniProtKB/Swiss-Prot Function]

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