Mouse Mgst2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mgst2
Locus ID	211666
Kit Components	GA213046G1, Mgst2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213046G2, Mgst2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213046G3, Mgst2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310482, NM_174995
Synonyms	GST2; MGST-II
Summary	Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (By similarity). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).[UniProtKB/Swiss-Prot Function]

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