Mouse Zfp521 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zfp521
Locus ID	225207
Kit Components	GA213760G1, Zfp521 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213760G2, Zfp521 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213760G3, Zfp521 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_145492, NM_181326, NM_001360804
Synonyms	B930086A16Rik; Evi3; Znf521
Summary	Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.[UniProtKB/Swiss-Prot Function]

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