Mouse Cecr2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cecr2
Locus ID	330409
Kit Components	GA216821G1, Cecr2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216821G2, Cecr2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216821G3, Cecr2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001128151, NM_001368706
Synonyms	2610101O16Rik; 2810409N01Rik; Gtl4; mKIAA1740
Summary	Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (By similarity). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development (PubMed:15640247, PubMed:20589882, PubMed:21246654). In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (PubMed:22154806). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (By similarity). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (By similarity).[UniProtKB/Swiss-Prot Function]

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