HIF1A / HIF1 alpha (1-85, His-tag) Human Protein
CAT#: AR09668PU-N
HIF1A / HIF1 alpha (1-85, His-tag) human recombinant protein, 50 µg
Size: 10 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDDMK
|
Tag | His-tag |
Predicted MW | 11.8 kDa |
Concentration | lot specific |
Purity | >80% by SDS – PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris buffer (pH 8.0) containing 20% glycerol, 1 mM DTT, 0.2M NaCl, 1 mM EDTA |
Preparation | Liquid purified protein |
Protein Description | Recombinant human Hif-1 alpha (1-85) protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001230013 |
Locus ID | 3091 |
UniProt ID | Q16665 |
Cytogenetics | 14q23.2 |
Synonyms | bHLHe78; HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8 |
Summary | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] |
Protein Families | Transcription Factors |
Protein Pathways | mTOR signaling pathway, Pathways in cancer, Renal cell carcinoma |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
Disturbance in the regulation of miR 17-92 cluster on HIF-1-α expression contributes to clinically relevant radioresistant cells: an in vitro study
,null,
Cytotechnology
,PubMed ID 31916114
[HIF1A]
|
p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions
,null,
International Journal of Molecular Sciences
,PubMed ID 30646538
[HIF1A]
|
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