Ferritin (heavy and light chain) Mouse Monoclonal Antibody [Clone ID: 090-10175]

Specifications

Product Data
Clone Name	090-10175
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Source: Human Spleen
Specificity	This antibody reacts to Ferritin (Spleen). Cross-reactivity for Liver Ferritin: 100%
Isotype	IgG2a
Formulation	10mM Phosphate, pH 7.4 containing 150mM Sodium chloride and 0,09% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	>90% pure (SDS-PAGE). Protein A chromatography. Product is 0.2µm filtered.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one week or (in aliquots) at -40°C for longer. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freezing and thawing.
Background	Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
Synonyms	FTH, FTL, Ferritin H subunit, Ferritin L subunit
Reference Data

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