Pdcd1lg2 Rat Monoclonal Antibody [Clone ID: TY25]

Specifications

Product Data
Clone Name	TY25
Applications	FC
Recommend Dilution	Flow cytometry (Neat - 1/5): use 10 µl of the suggested working dilution to label 106 cells in 100 µl.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	B7-DC transfected RAW264.7 cells. Lymph node cells from immunised SD rats were fused with the cells of the P3U1 myeloma cell line.
Specificity	This antibody clone TY25 recognizes Mouse CD273. This clone TY25 is reported to block the binding of CD273 (B7-DC) to it's receptor (Matsumoto et al. 2004). Removal of sodium azide is recommended prior to use in functional assays.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide and 1% BSA Label: FITC State: Liquid purified IgG fraction Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Gene Name	programmed cell death 1 ligand 2
Database Link	Entrez Gene 58205 Mouse UniProt ID Q9WUL5
Background	CD273 is a member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD279). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production.
Synonyms	PD-L2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1LG2, B7DC, PDCD1L2
Reference Data

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