DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]

Specifications

Product Data
Clone Name	TRAIL-R4-01
Applications	FC
Recommend Dilution	Flow Cytometry: 3 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Specificity	The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Isotype	IgG1
Formulation	PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent. Label: PE State: Liquid purified IgG fraction. Label: R-Phycoerythrin under optimum conditions
Concentration	lot specific
Purification	Size-Exclusion Chromatography.
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light.
Gene Name	tumor necrosis factor receptor superfamily member 10d
Database Link	Entrez Gene 8793 Human UniProt ID Q9UBN6
Background	TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Synonyms	TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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