CD300 antigen (CD300A) Mouse Monoclonal Antibody [Clone ID: MEM-260]

Specifications

Product Data
Clone Name	MEM-260
Applications	FC
Recommend Dilution	Suitable for Flow Cytometry analysis of Human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	HPB Human acute lymphoid leukemia cell line
Specificity	The antibody reacts with CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: PE State: Liquid purified IgG fraction Label: Conjugated with R-Phycoerythrin under optimum conditions
Purification	Size-Exclusion Chromatography
Conjugation	PE
Storage Condition	Store the antibody in the dark at 2-8°C. DO NOT FREEZE! Avoid prolonged exposure to light.
Gene Name	CD300a molecule
Database Link	Entrez Gene 11314 Human UniProt ID Q9UGN4
Background	CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.
Synonyms	CLM-8, CMRF35-H, CMRF35-H9, CMRF-35-H9, IRC1/IRC2, IRp60
Reference Data

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