Valproic Acid Mouse Monoclonal Antibody [Clone ID: 801]

Specifications

Product Data
Clone Name	801
Applications	ELISA
Recommend Dilution	May be used in immunoassays to detect and quantitate valproic acid.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Valproic acid conjugated to KLH
Specificity	This antibody reacts to valproic acid.
Isotype	IgG1
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Background	Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
Reference Data

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