BNP (NPPB) (1-32) Mouse Monoclonal Antibody [Clone ID: 50E1]

Specifications

Product Data
Clone Name	50E1
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot: detects a band of approximately 4kDa when using synthetic BNP and a band of 15kDa when using recombinant proBNP.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human synthetic BNP.
Specificity	This antibody detects an epitope located at the C-terminal (amino acids 26-32) of the brain natriuretic peptide (BNP), a secreted protein which is a member of the natriuretic peptide family. This antibody also detects proBNP.
Isotype	IgG1
Formulation	Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	natriuretic peptide B
Database Link	Entrez Gene 4879 Human UniProt ID P16860
Background	BNP is a cardiac hormone, which is synthesised as a pro-hormone (proBNP), and is proteolytically cleaved to release a biologically active fragment (BNP), and an inactive fragment (NT-proBNP) into the circulation. BNP is predominantly secreted from the cardiac ventricles in response to volume and pressure overload, and results in a number of biological activities including natriuresis, diuresis, vasorelaxation, and inhibition of the sympathetic nervous system. A high concentration of BNP in the bloodstream is indicative of heart failure.
Synonyms	NPPB
Reference Data

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