ORF45 ORF45 Mouse Monoclonal Antibody [Clone ID: 2D4A5]

Specifications

Product Data
Clone Name	2D4A5
Applications	IF, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500 - 1/2000.  Immunofluorescence: 1/200 - 1/1000.  Immunohistochemistry: 1/200 - 1/1000.
Reactivity	Kaposi-Sarkom-Herpesvirus
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Specificity	This antibody recognizes KSHV ORF45
Isotype	IgG1
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q2HR88
Background	Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Synonyms	KSHV, Human gammaherpesvirus 8, HHV-8
Reference Data

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