IRE1 (ERN1) (282-433) Mouse Monoclonal Antibody [Clone ID: 9F2]

Specifications

Product Data
Clone Name	9F2
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000 Western blot: 1/500-1/2000. Immunofluorescence: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human ERN1 (aa282-433) expressed in E. Coli.
Specificity	Recognizes ER To Nucleus Signaling 1 (IRE1/ERN1).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	109 kDa
Gene Name	endoplasmic reticulum to nucleus signaling 1
Database Link	Entrez Gene 2081 Human UniProt ID O75460
Background	IRE1p is a 108kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells.
Synonyms	Inositol-requiring protein 1, IRE1p, Ire1-alpha, IRE1a
Reference Data

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