PAX6 Mouse Monoclonal Antibody [Clone ID: 1C8]

CAT#: AM06472SU-N

PAX6 mouse monoclonal antibody, clone 1C8, Ascites



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CNY 5,346.00


货期*
5周

规格
    • 100 ul

Product images

Specifications

Product Data
Clone Name 1C8
Applications ELISA, FC, WB
Recommend Dilution Western Blot: 1/500 - 1/2000.
Flow cytometry: 1/200 - 1/400.
ELISA: 1/10000.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant fragment of human PAX6 expressed in E. Coli.
Specificity This antibody reacts to PAX6.
Formulation State: Ascites
State: Ascitic fluid containing 0.03% sodium azide.
Conjugation Unconjugated
Storage Condition

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Predicted Protein Size 46 kDa
Gene Name paired box 6
Background Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.
Synonyms Pax-6, Aniridia type II protein, AN2, Oculorhombin
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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