ABCG2 Mouse Monoclonal Antibody [Clone ID: 3G8]

Specifications

Product Data
Clone Name	3G8
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	Western Blot: 1/500-1/2000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000. Immunofluorescence: 1/200-1/1000. Flow Cytometry: 1/200-1/400. ELISA: 1/10000.
Reactivity	Human, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human ABCG2 expressed in E. Coli.
Specificity	This antibody reacts to ABCG2.
Isotype	IgG1
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	72 kDa
Gene Name	ATP binding cassette subfamily G member 2 (Junior blood group)
Database Link	Entrez Gene 9429 Human UniProt ID Q9UNQ0
Background	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Synonyms	Breast cancer resistance protein 1, ABCP, MXR
Reference Data

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