GSTM1 Mouse Monoclonal Antibody [Clone ID: 1H4A4]

Specifications

Product Data
Clone Name	1H4A4
Applications	ELISA, FC, IHC, WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. Immunohistochemistry on paraffin sections: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human GSTM1 expressed in E. Coli.
Specificity	This antibody reacts to GSTM1.
Formulation	State: Ascites State: Ascitic fluid containing 0.03% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	26 kDa
Gene Name	glutathione S-transferase mu 1
Database Link	Entrez Gene 2944 Human UniProt ID P09488
Background	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Synonyms	Glutathione S-transferase Mu 1, GST class-mu 1, GSTM1-1, GST1, GSTM1a-1a, GSTM1b-1b, GTH4
Reference Data

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