Cd40lg Hamster Monoclonal Antibody [Clone ID: MR1]

Specifications

Product Data
Clone Name	MR1
Applications	FC
Recommend Dilution	Flow Cytometry: < / 2 µg/10e6 cells. (Ref.1,5)
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Activated mouse Th1 clone D1.6 (Ref.1)
Specificity	This antibody is specific to CD154 (CD40 ligand/gp39), Mr 39-kDa.
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD40 ligand
Database Link	Entrez Gene 21947 Mouse UniProt ID P27548
Background	CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. (Ref.1-7) It is an important accessory molecule in T cell-B cell costimulatory interactions, and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporinsensitive. (Ref.6) The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. (Ref.1,5) Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens, yet does not alter the immune response to TI antigens. (Ref.4)
Synonyms	CD40 ligand, CD40-L, CD40LG, TNFSF5, TRAP, GP39
Reference Data

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