Eng Rat Monoclonal Antibody [Clone ID: MJ7/18]

Specifications

Product Data
Clone Name	MJ7/18
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry: Identification and enumeration of CD105+ cells. (< / = 1 µg/10e6 cells). (Ref.1) Immunohistochemistry on Frozen Sections. Western Blotting. (Ref.1)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Inflamed mouse skin. (Ref.1)
Specificity	This antibody recognises Mouse Endoglin/CD105 (Mr. 90kDa)
Isotype	IgG2a
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	endoglin
Database Link	Entrez Gene 13805 Mouse UniProt ID Q63961
Background	CD105/endoglin is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells. (Ref.2) Both mouse and human CD105 exhibit > 70% sequence homology in their cytoplasmic domains with type III Transforming Growth Factor beta (TGF-beta) receptor. (Ref.3) CD105 has been shown to be one of several receptors for the various isoforms of TGF-beta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response. (Ref.4)
Synonyms	ENG, END, HHT1, ORW, ORW1
Reference Data

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