H2-D1 Mouse Monoclonal Antibody [Clone ID: 27-11-13S]

Specifications

Product Data
Clone Name	27-11-13S
Applications	CT, FC
Recommend Dilution	Flow Cytometry (See Ref.2) Immunohistochemistry: Acetone-Fixed, Frozen Tissue Sections only. Complement-mediated cytotoxicity (See Ref.1,2) Immunocytochemistry (See Ref. 3). CMCD (Reported in Ref.1).
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	BDF1 mouse splenocytes. (Ref.1)
Specificity	This antibody recognizes the alpha 3 domain of H-2Db class I MHC antigen. It cross-reacts with the alpha 3 domain of H-2Ld, H-2Dq and H-2Lq, but not H-2Kd or H-2Dd. Reactivity with haplotypes k, f, p, r, and s has not been observed. Customer feedback: Clone 27-11-13S does not cross-react with Human cells.
Isotype	IgG2a
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	histocompatibility 2, D region locus 1
Database Link	Entrez Gene 14964 Mouse UniProt ID P01899
Background	In the mouse the MHC Class 1 loci are called H2K, H2L and H2D. The equivalent loci in the human MHC are HLA (Human Leukocyte Antigen). MHC class I molecules are heterodimers, consisting of a single transmembrane polypeptide chain (the a-chain) which is highly polymorphic, and the invariant beta 2 Microglobulin (which is encoded elsewhere, not in the MHC). MHC class I molecules are found on almost every nucleated cell of the body. Their major function is to present peptide fragments derived from antigens to cytotoxic T cells.
Synonyms	H-2D(B), H2-D1
Reference Data

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