Perforin (PRF1) (C-term) Mouse Monoclonal Antibody [Clone ID: 5B10]

CAT#: AM08218SU-N

Perforin (PRF1) (C-term) mouse monoclonal antibody, clone 5B10, Supernatant



Need it in bulk or conjugated?
Get a free quote

CNY 11,606.00


货期*
4周

规格
    • 1 ml

Product images

Specifications

Product Data
Clone Name 5B10
Applications IHC
Recommend Dilution Immunohistochemistry on Paraffin Embedded Sections: 1/10-1/20 in an ABC method (60 minutes at room temperature).
Paraffin-embedded tissue sections require high temperature antigen unmasking using 10 mM citrate buffer, pH 6.0 prior to immunostaining.
Positive Control: Spleen.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant protein corresponding to an external region of the C-terminus of the perforin molecule.
Specificity This antibody is specific to a 70 kD protein, which is a potent cytolytic pore-forming protein.
Cellular Localization: Cytoplasmic.
Formulation State: Supernatant
State: Tissue Culture Supernatant containing Sodium Azide as a preservative.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name perforin 1
Background Perforin is one of the major cytolytic proteins of cytolytic granules. One of the main pathways of lymphocyte mediated cytolysis entails the secretion onto target membranes of cytolytic granules contained in cytolytic effector lymphocytes of T cell or NK cell type. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Perforin is involved in the killing mediated by cytotoxic lymphocytes, which represents an important mechanism in the immune defense against tumors and virus infections. Human perforin is a 555 amino acid protein with a 21 amino acid signal peptide. It has a molecular weight of 70 to 75 kDa. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9 and homology between perforin and C9 has been demonstrated at their respective functionally conserved regions. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested.
Synonyms Perforin-1, Pore forming protein, PFN, PFP, Cytolysin
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...