CD15 Mouse Monoclonal Antibody [Clone ID: HI98]

Specifications

Product Data
Clone Name	HI98
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 1/50.
Reactivity	Human, Chimpanzee
Host	Mouse
Clonality	Monoclonal
Immunogen	Human PBMCs
Specificity	This antibody reacts to Human Fucosyltransferase 4 (alpha (1,3) Fucosyltransferase, Myeloid-specific) (FUT4/CD15).
Isotype	IgM
Formulation	PBS, pH 7.2 containing 0.09% Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Background	The CD15 antigen is expressed on approximately 90% human circulating granulocytes (membranes and granules), 30 to 60% of circulating monocytes and is absent from normal lymphocytes. CD15 antigen is also expressed on Reed Sternberg cells of Hodgkin's disease, on T cell lymphomas including mycosis fungoides and on some leukemias. Outside the hematopoietic system, CD15 expression is described in certain normal and neoplastic epithelial cells and in astrocytes. At least 5 major CD15 antigens (105, 135, 165, 185, 220 kDa) are present on the surface membranes of polymorphonuclear cells. The hapten occurs also in glycolipids. CD15 plays a role in mediating phagocytosis, bactericidal activity and chemotaxis.
Synonyms	Lewis X, X-Hapten, Lacto-N-Fucopentaose III, Stage-Specific Embryonic Antigen, SSEA1
Reference Data

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