TDP43 (TARDBP) Mouse Monoclonal Antibody [Clone ID: k1B8]

Specifications

Product Data
Clone Name	k1B8
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1/1,000-1/2,000).  Flow Cytometry. Immunohistochemistry on Paraffin Sections (1/50-1/100).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TARDBP (1-260 aa) purified from E. coli.
Specificity	The antibody recognizes Human TARDBP. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TAR DNA binding protein
Database Link	Entrez Gene 23435 Human UniProt ID Q13148
Background	TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
Synonyms	TDP43, TDP-43
Reference Data
Protein Families	Transcription Factors

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