Lamin A (LMNA) Mouse Monoclonal Antibody [Clone ID: R27]

Specifications

Product Data
Clone Name	R27
Applications	IF, IHC, WB
Recommend Dilution	Immunofluorescence Microscopy. Immunoblotting (Western). Working Dilution: Ready-to-use for Immunofluorescence microscopy. Incubation Time: 1 h at RT.
Reactivity	Bovine, Fish, Human, Mouse, Rat, Xenopus, Zebrafish
Host	Mouse
Clonality	Monoclonal
Immunogen	Nuclear pore complex-lamina fraction of Bovine liver.
Specificity	The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope. Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in Human and Mouse and other laminopathies (for review see Burke & Stewart, 2002). Polypeptide(s) Reacting: Lamin isotypes A and C (Mr 60-75 kD); meiotic lamin C2. Tested Reactivity on Cultured Cell Lines: RV-SMC (Rat Vascular Smooth Muscle Cells).
Isotype	IgM
Formulation	State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	lamin A/C
Database Link	Entrez Gene 16905 MouseEntrez Gene 60374 RatEntrez Gene 4000 Human UniProt ID P02545
Background	Lamin A and lamin C are alternative splicing products of the lamin A/C gene that is responsible for autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD). Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. Lamins A and C, the products of the LMNA gene, are nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope.
Synonyms	LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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