hCG beta (CGB3) Mouse Monoclonal Antibody [Clone ID: HCG205]

Specifications

Product Data
Clone Name	HCG205
Applications	IHC
Recommend Dilution	Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears) For IHC dilute concentared antibody at 1/50-1/100, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature. Antigen retriever like citrate enhances the staining of FFPE tissue sections (Boil tissue in 10 mM citrate, pH 6.0 for 10-15 minutes followed by cooling for 10-15 minutes at RT. Recommended Positive Control: Human placenta, choriocarcinoma.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified beta hCG.
Specificity	This antibody recognises Human Chorionic Gonadotropin (hCG). Cellular Localization: Cytoplasmic.
Isotype	IgG1
Formulation	PBS, pH 7.4 containing 1% BSA as stabilizer and 0.05% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	chorionic gonadotropin beta subunit 3
Database Link	Entrez Gene 1082 Human UniProt ID P0DN86
Background	Human chorionic gonadotropin (hCG) is a oligosaccharide glycopeptide hormone (244 aa) produced in pregnancy that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions; for instance, it is thought that hCG affects the immune tolerance of the pregnancy. Early pregnancy testing, in general, is based on the detection or measurement of hCG. HCG is compose of two non-identical, non-covalently linked polypeptide chains as α and β-subunits. The α subunit of hCG is nearly identical to that of thyroid stimulating (TSH), FSH, and LH.A germ cell tumor which is + for Cytokeratin, PLAP, and hCG but negative for EMA and alpha feto protein is probably choriocarcinoma
Synonyms	Choriogonadotropin subunit beta, CGB, CGB3, beta hCG, hCG-beta
Reference Data

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