p27 KIP 1 (CDKN1B) Mouse Monoclonal Antibody [Clone ID: SX53G8]

Specifications

Product Data
Clone Name	SX53G8
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Colon carcinoma.
Reactivity	Canine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified glutathione S-transferase (GST)-p27Kip1 fusion protein.
Specificity	Recognizes p27Kip1. Clone SX53G8 co-precipitates cdk4 in complex with p27Kip1 and is excellent for staining of formalin fixed tissues. Cellular Localization: Nuclear.
Isotype	IgG1
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	cyclin-dependent kinase inhibitor 1B
Database Link	Entrez Gene 18039 MouseEntrez Gene 83613 RatEntrez Gene 1027 Human UniProt ID P46527
Background	p27Kip1, a candidate tumor suppressor gene, functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-beta induced G1 arrest.
Synonyms	p27Kip1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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