UBE2I Mouse Monoclonal Antibody [Clone ID: 67AT1273.95.90]

Specifications

Product Data
Clone Name	67AT1273.95.90
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	purified GST-UBC9 fusion protein.
Specificity	This antibody is specific to UBC9.
Isotype	IgG1
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ubiquitin conjugating enzyme E2 I
Database Link	Entrez Gene 7329 Human UniProt ID P63279
Background	Human Ubquitin Conjugating Enzyme 9 (Ubc9) is a member of the E2 family and is specific for the conjugation of SUMO to a variety of target proteins. SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. This E2 is unusual in that it interacts directly with protein substrates that are modified by sumoylation, and may play a role in substrate recognition. Ubc9 can mediate the conjugation of SUMO-1 to a variety of proteins including RanGAP1, IκBalpha, and PML without the requirement of an E3 ligase. Ubc9 is essential for nuclear architecture and chromosome segregation.
Synonyms	UBCE9, Ube2i, Ubce2i, SUMO-protein ligase
Reference Data

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