CDK6 Mouse Monoclonal Antibody [Clone ID: IML-6]

Specifications

Product Data
Clone Name	IML-6
Applications	IF, WB
Recommend Dilution	Western Blot: 0.1 - 0.5 μg/ml. Immunocytochemistry: 1 ug/ml.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Cdk6 protein.
Specificity	This antibody reacts to CDK6.
Isotype	IgG1
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Purified by the goat anti-mouse IgG affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cyclin-dependent kinase 6
Database Link	Entrez Gene 12571 MouseEntrez Gene 114483 RatEntrez Gene 1021 Human UniProt ID Q00534
Background	The cyclin-dependent protein kinases (CDKs) regulate major cell cycle transitions in eukaryotic cells.Cyclin-dependent kinase-6 (CDK6) is the earliest inducible member of the CDK family in human T lymphocytes, involved in growth factor stimulation and cell cycle progression. germline mutations in CDK6 do not make a significant contribution to melanoma predisposition. CDK6 gene is mapped at 7q21-q22.
Synonyms	PLSTIRE
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer

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