LRG1 Mouse Monoclonal Antibody [Clone ID: 2F5.A2]

Specifications

Product Data
Clone Name	2F5.A2
Applications	ELISA
Recommend Dilution	Immuno assays (1,2): Antibody was used as detector for LRG on cytochrome C coated plates. Concentration antibody used was 1 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human LRG, covalently coupled to hemocyanin using glutaraldehyde
Specificity	The monoclonal antibody recognizes leucine-rich alpha-2-glycoprotein (LRG), a member of the leucine-rich repeat family. It can be used for immuno purification of Human LRG.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	leucine-rich alpha-2-glycoprotein 1
Database Link	Entrez Gene 116844 Human UniProt ID P02750
Background	LRG is a plasma protein of approximately 50 kDa. LRG consists of 312 amino acids. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312 amino acids, and LRG contains at least eight 24-amino acid leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells.
Synonyms	Leucine-rich alpha-2-glycoprotein, LRG
Reference Data

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