MGO-modified proteins Mouse Monoclonal Antibody [Clone ID: MGO-1]

Specifications

Product Data
Clone Name	MGO-1
Applications	ELISA, IHC, WB
Recommend Dilution	Immunoassays. Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50. Western blot.
Reactivity	var.
Host	Mouse
Clonality	Monoclonal
Immunogen	MGO-modified KLH
Specificity	The monoclonal antibody MGO-1 recognizes human MGO modified proteins.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Background	Methylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. A number of studies have shown that MGO levels are significantly elevated in patients with Type 2 Diabetes and correlates well with fasting plasma glucose and hemoglobin A1c (HbA1c) levels. Moreover, increased formation of the MGO is implicated in renal dysfunction and is known to be involved in the development of DN (diabetic nephropathy).
Reference Data

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