DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: UW60.1]

Specifications

Product Data
Clone Name	UW60.1
Applications	FC, IF
Recommend Dilution	Flow Cytometry. Immunohistochemistry. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	CD209-His-tagged fusion protein
Specificity	The mouse monoclonal antibody UW60.1 recognizes CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.
Isotype	IgG2a
Formulation	PBS, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide
Concentration	lot specific
Purification	Protein-A affinity chromatograpy ( > 95% by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	CD209 molecule
Database Link	Entrez Gene 30835 Human UniProt ID Q9NNX6
Background	CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).
Synonyms	DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker
Reference Data

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