HLA DM (HLA-DMA) Rat Monoclonal Antibody [Clone ID: M5/114]

Specifications

Product Data
Clone Name	M5/114
Applications	FC
Recommend Dilution	Flow Cytometry: 4 µg/ml (starting point).
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Activated C57BL/6 mouse spleen cells
Specificity	The antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
Isotype	IgG2b
Formulation	Phosphate buffered saline (PBS), approx. pH 7.4 Label: FITC State: Liquid purified Ig fraction Preservative: 15 mM sodium azide
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	major histocompatibility complex, class II, DM alpha
Database Link	UniProt ID P28067
Background	MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.
Synonyms	DMA, RING6, MHC class II antigen DMA
Reference Data

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