Mannose Receptor (MRC1) Mouse Monoclonal Antibody [Clone ID: 15-2]

Specifications

Product Data
Clone Name	15-2
Applications	FC, FN, IF, IHC, IP, WB
Recommend Dilution	Flow cytometry. Immunoprecipitation. Western blot. Immunohistochemistry (frozen sections). Immunocytochemistry. Functional application: blocking.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human mannose receptor
Specificity	This antibody clone 15-2 (also known as MR15-2) recognizes CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	mannose receptor, C type 1
Database Link	Entrez Gene 4360 Human UniProt ID P22897
Background	CD206 (macrophage mannose receptor, MMR), also known as mannose receptor C1 (MRC1), is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.
Synonyms	Macrophage mannose receptor, CLEC13D, CLEC13DL, MRC1L1
Reference Data

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