CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-R3]

Specifications

Product Data
Clone Name	B-R3
Applications	FC, FN
Recommend Dilution	Flow Cytometry. Functional Assay: Inhibits IL-6, IL-11, CNTF, LIF and OSM activities. Inhibits OSM and CNTF binding to gp130.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Natural soluble gp130.
Specificity	Recognises the soluble antigen. Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Isotype	IgG2a
Formulation	PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 6 signal transducer
Database Link	Entrez Gene 3572 Human UniProt ID P40189
Background	CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms	Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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