PRUNE (PRUNE1) Mouse Monoclonal Antibody [Clone ID: 1C11]

Specifications

Product Data
Clone Name	1C11
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein
Specificity	This antibody recognizes Human PRUNE.
Isotype	IgG2a
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	prune exopolyphosphatase
Database Link	Entrez Gene 58497 Human UniProt ID Q86TP1
Background	PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
Synonyms	Protein prune homolog, hPrune, HTcD37, DRES17, DRES-17
Reference Data
Protein Pathways	Purine metabolism

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