MVP Mouse Monoclonal Antibody [Clone ID: LRP-56]

Specifications

Product Data
Clone Name	LRP-56
Applications	IF, IHC
Recommend Dilution	Flow Cytometry: Use at least 1/50. Cell permeabilization required with 10% lyzing solution followed by primairy antibody and anti-Mouse-FITC. Immunocytochemistry: Use at least 1/20-1/50 on Aceton fixed cell preparation. Immunohistochemstry on Acetone-Fixed Frozen Sections: at least 1/20-1/50. Immunohistochemstry on Formalin-Fixed Paraffin Embedded Tissues: 1/20.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This Monoclonal antibody LRP-56 reacts with an internal epitope of the LRP-protein (P110), which is strongly over-expressed in various Human non-P-glycoprotein MDR tumor cell lines.
Isotype	IgG2b
Formulation	State: Supernatant State: Liquid Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for 3 months or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	major vault protein
Database Link	Entrez Gene 9961 Human UniProt ID Q14764
Background	This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
Synonyms	MVP, LRP
Reference Data

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