Cd8a Mouse Monoclonal Antibody [Clone ID: ANK44]

Specifications

Product Data
Clone Name	ANK44
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry. Immunoprecipitation. Immunohistochemical on Frozen Sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The ANK44 monoclonal antibody was generated by immunizing mice with IL-2-activated cultured NK cells of Wag rats (Giezeman-Smits et al., 1998).
Specificity	The antigen recognized by this Monoclonal antibody ANK44 is highly expressed on Rat NK cells after IL-2-activation. The antigen is not expressed by unstimulated NK cells. ANK44 also binds to Rat gamma/delta-TCR T cells. It does not bind to alpha/beta-TCR T cells or to B cells. The ANK44 Monoclonal antibody is Rat strain-independent.
Isotype	IgG1
Formulation	State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.05% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for Two months or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD8a molecule
Database Link	Entrez Gene 24930 Rat UniProt ID P07725
Background	Natural Killer Cells (NK) are large, granular, bone-marrow derived lymphocytes and are a component of innate immune defense. They are activated in response to interferons or macrophage-derived cytokines. Rather than destroying the attacking microorganisms directly, NK cells attack cells that have been infected by the microbes. NK cells contain special proteins in their cytoplasm, such as proteases called granzymes as well as Perforin. Perforin makes pores in the target cell membrane, allowing the granzymes, water and ions to diffuse into the cell. This causes expansion of the cell until it eventually lyses under pressure. Individuals who lack NK cells are highly susceptible to early phases of herpes virus infection.
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data

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