CD46 Mouse Monoclonal Antibody [Clone ID: AT2G9]

Specifications

Product Data
Clone Name	AT2G9
Applications	ELISA, FACS, FC, ICC/IF, IF, IHC, WB
Recommend Dilution	ELISA. Western blot. Flow cytometry. Immunofluorescence/Immnunocytochemistry. Immunohistochemistry on Paraffin Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CD46 (35-313aa) purified from E. coli
Isotype	IgG2a, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	CD46 molecule
Database Link	NP_758860 Entrez Gene 4179 Human UniProt ID P15529
Background	Membrane Cofactor Protein (CD46) is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. This protein is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is implicated in the development and/or progression of selected cancer types.
Synonyms	Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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