Frizzled 7 (FZD7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 61-110 of Human Frizzled-7.
Specificity	This antibody detects endogenous levels of Frizzled-7 protein. (region surrounding Tyr87)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction. Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 64, 85 kDa
Gene Name	frizzled class receptor 7
Database Link	Entrez Gene 8324 Human UniProt ID O75084
Background	The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins: FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt. frizzled-7 has a Lys-Thr-X-X-X-Trp motif which is involved in the activation of the Wnt/beta-catenin signaling pathway. frizzled-7 is an integral membrane protein showing a high expression in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain and placenta. It is specifically expressed in squamous cell esophageal carcinomas.
Synonyms	Fz-7, mFz7
Reference Data

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