SH3BP2 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: Detects a 85 kDa band in murine fibroblasts transfected with 3BP2.
Reactivity	Mouse
Host	Sheep
Clonality	Polyclonal
Immunogen	Antibody developed using SH2 domain of the 3BP2 protein fused to GST.
Specificity	This antibody reacts to 3BP2.
Isotype	IgG
Formulation	Phosphate buffered saline and 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	SH3 domain binding protein 2
Database Link	Entrez Gene 24055 Mouse UniProt ID P78314
Background	3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLCg 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66% homologous to the human protein at the amino acid level.
Synonyms	SH3 domain-binding protein 2, SH3BP-2, 3BP2, 3BP-2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Natural killer cell mediated cytotoxicity

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