IL23 (IL23A) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1-2 µg/ml. Detects a band of approximately 24kDa in Raji cell lysates. Immunocytochemistry.  Immunohistochemistry on Frozen Sections: 10 µg/ml. Positive control tissue: Raji cells.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 14 amino acid peptide from near the carboxy-terminus of human IL-23
Specificity	This antibody detects an epitope within the C-terminal (CT) domain of Human Interleukin-23 (IL-23).
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid purified IgG fractioon Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 23 subunit alpha
Database Link	Entrez Gene 83430 MouseEntrez Gene 51561 Human UniProt ID Q9NPF7
Background	IL23 is a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses. IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.
Synonyms	IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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