MEK5 (MAP2K5) pSer311/pThr315 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; detects a band of approximately 49kDa in rat testes cell lysates.
Reactivity	Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat, Xenopus, Zebrafish
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within MEK5 , which includes phoshorylated Ser311 and Thr315.
Specificity	This antibody specifically recognises 49kDa MEK5, also known as MAP2K5, when phosphorylated at Ser311 and Thr315. Activation of MEK5 itself is regulated by upstream MAP3K3/MEKK3, and phosphorylation of MEK5 at both the Ser311 and Thr315 sites has been implicated in cell proliferation.
Isotype	IgG
Formulation	10mM Hepes pH7.5 containing 0.09% Sodium Azide (NaN3), 0.01% Bovine Serum Albumin, 50% Glycerol State: Purified State: Liquid purified IgG
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mitogen-activated protein kinase kinase 5
Database Link	Entrez Gene 5607 Human UniProt ID Q13163
Background	MEK5 is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family, which acts as a key regulator in a mitogen-activated protein (MAP) kinase cascade, and hence growth factor-induced cellular stimulation. MEK5 exists in naturally occurring MEK5alpha and MEK5beta splice variants, the former of which is known to specifically activate/regulate MAPK7/ERK5/BMK1, whilst the latter may act as a suppressor of MAPK7 activation.
Synonyms	MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
Reference Data

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