DARPP32 (PPP1R1B) pThr34 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:1000; detects a band of approximately 32kDa in rat caudate lysates.
Reactivity	Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within DARPP-32 which includes phosphorylated Thr34.
Specificity	This antibody is specific for DARPP-32, when phosphorylated at threonine 34.
Isotype	IgG
Formulation	10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.1% Bovine Serum Albumin and 50% Glycerol State: Purified State: Liquid purified Ig
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein phosphatase 1 regulatory inhibitor subunit 1B
Database Link	Entrez Gene 84152 Human UniProt ID Q9UD71
Background	DARPP-32 (also known as protein phosphatase 1 regulatory subunit 1B PP1R1B) is a dopamine- and cAMP-regulated phosphoprotein, which is principally expressed in striatal medium spiny neurons, and is thought to play a critical role in the regulation of dopaminergic neurotransmission. DARPP-32 can act either as a phosphatase inhibitor or as a kinase inhibitor, depending on its relative state of phosphorylation . Phosphorylation at threonine 34 converts DARPP-32 into an inhibitor of protein phosphatase-1 (PP-1) whilst phosphorylation at threonine 75 switches the protein to an inhibitor of protein kinase A (PKA) .
Synonyms	PPP1R1B, DARPP-32, FLJ20940
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.