p39 (CDK5R2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/500.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 71-122 of Human CDK5R2.
Specificity	This antibody detects endogenous levels of p39 protein. (region surrounding asn100)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 39 kDa
Gene Name	cyclin-dependent kinase 5 regulatory subunit 2
Database Link	Entrez Gene 12570 MouseEntrez Gene 8941 Human UniProt ID Q13319
Background	Cyclin dependent kinases, known as Cdks, regulate transitions in the eukaryotic cell cycle. Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons. Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39. The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39 kDa protein. p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins. During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain. p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons. In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells. The temporal and spatial expression of p39 in synaptic junctions indicates a possible role of the p39/cdk5 kinase at the synapse.
Synonyms	CDK5 activator 2,P39, P39I, NCK5AI
Reference Data
Protein Families	Druggable Genome

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.